Non-cirrhotic portal hypertension (NCPH) comprises a heterogeneous group of liver disorders causing portal hypertensionwithout\ncirrhosis and carries a high risk of variceal bleeding. Recent guidelines, based largely on patients with viral cirrhosis, suggest low\nlikelihood of high risk varices (HRV) in patients with a liver stiffness measurement (LSM) <20 kPa and platelet count >150 Ã? 10^9/L.\nIn NCPH, LSMis often higher than healthy controls but lower than matched cirrhotic patients. The aim of this study was to assess\nwhether LSMor other noninvasive assessments of portal hypertension could predict HRV in NCPH patients. Methods. Records of\npatients with NCPH seen at a single centre between 2007 and 2018 were reviewed retrospectively. Primary outcome measure was\npresence or absence of HRV at gastroscopy within 12 months of clinical assessment. Association of LSM or other clinical features\nof portal hypertension (spleen size, platelet count, platelet count/spleen length ratio (PSL), LSM-spleen length/platelet count ratio\nscore (LSP)) with HRV and ability of these variables to predict HRV was analysed. Results. Of 44 patients with NCPH who met\ninclusion criteria, 34% (15/44) had HRV. In amultivariate model, spleen size and PSL correlated with HRV but platelet count, LSM,\nand LSP did not (spleen size.............................
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